Physical Damage is used to calculate Physical Damage that a hero can deal. It is can be reduced by enemy's Physical Armor.

Magic Damage is used to calculate Magic Damage that a hero can deal. It is usually reduced by enemy's Magic Armor.

Crit Chance determines the chance to land a Critical hit for most attacks.

Crit Damage determines the amount of extra Damage or Heal from Critical Hit attacks.

Penetration is used to calculate the Damage dealt by abilities, but not the status effects. Reduces enemy's Physical and Magical Armor.

Accuracy shows a chance to land a hit on an enemy with most abilities.