Potency is a crucial stat that determines a chance to inflict a negative status effect aka debuff.
While in the battle, you can tap and hold the Buff icon and read what it does.
Here's a list of heroes who can apply Potency Increase:
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Victoria (Ability 3)
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Mara (Passive Ability)
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Solius (Leadership Ability)
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Rantha (Leadership Ability)
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Korkhrim (Passive Ability)
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Sabator (Passive Ability and Ability 2)
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Tromgar (Leadership Ability and Ability 3)
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Zerra (Leadership Ability)
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Nightiel (Ability 3)
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Kiana (Passive Ability)
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Thalanne (Passive Ability)
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Old Loor (Ability 3)
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Instructor Gorram (Ability 3)
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McRat (Leadership Ability)
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General Murdock (Passive Ability)
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Hilda ( (Passive Ability and Ability 2)
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Kang Xi (Ability 3)
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Lake (Leadership Ability)
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Lei Zi (Passive Ability)
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Ember (Passive Ability)
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Yogi (Passive Ability)
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Sindri (Ability 3)
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Zappy (Ability 3)
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Hell Kitty (Ability 3)
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Archi & Ro (Passive Ability)
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Bar & Rel (Ability 3)
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Drago & Nas (Ability 3)
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Keb & Bab (Ability 3)
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Buff (Ability 2 and 3)